| Abstract |
Maternal obesity (MO) increases the risk of later-life liver disease in offspring, especially in males. This may be due to impaired cytochrome P450 (CYP) enzyme activity driven by an altered maternal-fetal hormonal milieu. MO increases fetal cortisol concentrations that may increase CYP activity; however, glucocorticoid receptor (GR)-mediated signaling can be modulated by alternative GR isoform expression. We hypothesized that MO induces sex-specific changes in GR isoform expression and localization that contribute to reduced hepatic CYP activity. |
| Authors |
Ashley S. Meakin  , Peter W. Nathanielsz  , Cun Li , Hillary F. Huber , Vicki L. Clifton , Michael D. Wiese , Janna L. Morrison
|
| Journal Info |
Wiley | Obesity
|
| Publication Date |
8/29/2024 |
| ISSN |
1930-7381 |
Type |
article |
| Open Access |
hybrid
|
| DOI |
https://doi.org/10.1002/oby.24124 |
| Keywords |
Hepatic function (Score: 0.5275005)
|
