Detailed Record



LEA_4 motifs act synergistically with drying-enriched metabolites to increase their protective ability


Abstract Intrinsically disordered Family 4 Late Embryogenesis Abundant (LEA_4) proteins are important in many organisms' ability to survive extreme drying, or desiccation. Interestingly, these proteins adopt novel structures upon desiccation, which is thought to confer their protective capabilities. Specifically, it is believed that conserved 11-residue motifs in LEA_4 proteins become more helical in water deficient environments, which enables them to protect sensitive proteins in the cell. However, this is not the only situation in which LEA_4 protein structure is altered.
Authors Vincent Nicholson University of Wyoming , Kenny Nguyen University of WyomingORCID , Feng Ye ORCID , Shahar Sukenik ORCID , Thomas E. Boothby University of WyomingORCID
Journal Info Elsevier BV | Biophysical Journal , vol: 122 , iss: 3 , pages: 346a - 347a
Publication Date 2/1/2023
ISSN 0006-3495
TypeKeyword Image article
Open Access hybrid Hybrid Access
DOI https://doi.org/10.1016/j.bpj.2022.11.1925
KeywordsKeyword Image LEA Proteins (Score: 0.551779)