| Abstract |
Right ventricular (RV) function predicts survival in age-related disease, yet mechanisms of RV failure are unclear. We show that aged mice undergo exacerbated RV remodeling compared with young. We tested the AMPK activator metformin to improve RV function and show that metformin attenuates RV remodeling only in adult male mice via a mechanism that does not require cardiac AMPK. Metformin is therapeutic for RV dysfunction in an age- and sex-specific manner independent of cardiac AMPK. |
| Authors |
Benjamin D. McNair  , Sydney M. Polson , Samantha K. Shorthill , Aykhan Yusifov , Lori A. Walker  , Mary C.M. Weiser‐Evans , Elizabeth J. Kovacs , Danielle R. Bruns
|
| Journal Info |
American Physical Society | American Journal of Physiology: Heart and Circulatory Physiology , vol: 325
, iss: 2
, pages: H278 - H292
|
| Publication Date |
8/1/2023 |
| ISSN |
0363-6135 |
Type |
article |
| Open Access |
closed
|
| DOI |
https://doi.org/10.1152/ajpheart.00124.2023 |
| Keywords |
Left Ventricular Function (Score: 0.587078) , Right Heart Assessment (Score: 0.510554)
|
