| Abstract |
The mitochondria, apart from balancing optimal cellular homeostasis and energetics to sustain life, also mediate pathophysiological mechanisms leading to injury and death. In this regard, mitochondrial transplantation is emerging as a novel therapeutic strategy to circumvent deleterious effects of mitochondrial dysfunction in various pathological disorders. The transplantation of mitochondria involves the process of isolation, selection of optimal mitochondria, transfer, and internalization of exogenous intact mitochondria into the target cells or tissue. In the myocardium, metabolic and ionic changes secondary to the lack of oxygen are major contributors to mitochondrial damage. Mitochondrial transplantation has been demonstrated to protect against cardiac ischemia-reperfusion injury. |
| Authors |
Yuhao Li  , Kroekkiat Chinda , Yaozu Xiang , Hao Zhang  , Dan Xu , Sang‐Ging Ong , Sang-Bing Ong
|
| Journal Info |
Elsevier BV | Molecular Therapy , vol: 31
, iss: 5
, pages: 1201 - 1203
|
| Publication Date |
5/3/2023 |
| ISSN |
1525-0016 |
Type |
article |
| Open Access |
hybrid
|
| DOI |
https://doi.org/10.1016/j.ymthe.2023.04.003 |
| Keywords |
Transplantation (Score: 0.552974) , Heart Transplant (Score: 0.529694) , Mitochondria (Score: 0.511134) , Mitochondrial Dysfunction (Score: 0.506713) , Mitochondrial Fission (Score: 0.505096)
|
