Detailed Record


Reprogramming of breast tumor–associated macrophages with modulation of arginine metabolism


Abstract HER2+ breast tumors have abundant immune-suppressive cells, including M2-type tumor-associated macrophages (TAMs). Although TAMs consist of the immune-stimulatory M1 type and immune-suppressive M2 type, the M1/M2-TAM ratio is reduced in immune-suppressive tumors, contributing to their immunotherapy refractoriness. M1- versus M2-TAM formation depends on differential arginine metabolism, where M1-TAMs convert arginine to nitric oxide (NO) and M2-TAMs convert arginine to polyamines (PAs). We hypothesize that such distinct arginine metabolism in M1- versus M2-TAMs is attributed to different availability of BH
Authors Veani Fernando ORCID , Xunzhen Zheng , Vandana Sharma University of WyomingORCID , Osama Sweef ORCID , Eun‐Seok Choi ORCID , Saori Furuta ORCID
Journal Info | Life Science Alliance , vol: 7 , iss: 11 , pages: e202302339 - e202302339
Publication Date 8/27/2024
ISSN 2575-1077
TypeKeyword Image article
Open Access gold Gold Access
DOI https://doi.org/10.26508/lsa.202302339
KeywordsKeyword Image Reprogramming (Score: 0.48494437)